Anti-Cancer Studies

Our Lab focuses on developing Anti-cancer drugs primarily for the drug targets of FGFR and relative kinases. We are also searching for relative mechanisms that cause cancer. In addition to that, Circadian rhythms are autonomous oscillators developed by the molecular circadian clock, essential for coordinating internal time with the external environment in a 24-h daily cycle. In mammals, this circadian clock system plays a significant role in all physiological processes and severely affects human health. The regulation of the circadian clock extends beyond the clock genes to involve several clock-controlled genes. Hence, the aberrant expression of these clock genes leads to the down-regulation of essential targets that control the cell cycle and the ability to undergo apoptosis. This may lead to genomic instability and promotes carcinogenesis. Alteration in the clock genes and their modulation is recognized as a new approach for developing effective treatments against several diseases, including cancer. Until now, there has been a lack of understanding of circadian rhythms and cancer disease and our group is working on it.